Anxiety Disorders An Introduction to Clinical Management and by Eric J.L. Griez

By Eric J.L. Griez

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POST-TRAUMATIC STRESS DISORDER (PTSD) The DSM-IV definition for PTSD contains criteria for (a) the traumatic experience; 16 ———————————— T. OVERBEEK, E. L. GRIEZ (b) re-experiencing; (c) avoidance of associated stimuli and numbing; and (d) increased arousal. Duration of symptoms should be at least one month (e); and (f ) distress or impairment in functioning is required (APA, 1994). When PTSD was first defined in DSM-III (APA, 1980), the original stressor criterion characterised traumatic experiences as being outside the range of human experience.

For this reason, genes coding for serotonergic structures may be appropriate candidate genes, playing the main aetiologic role in OCD. , 1996) exclude for the available clinical populations a major or slight effect of these elements in the OCD development. , 1993). , 1998) has been described. Also, the gene for the serotonin transporter, that re-uptakes serotonin in the intersynaptic cleft, thus a probable action site of SRI, may be a candidate gene in OCD. , 1996) did not highlight specific variations in the sequence of serotonin transporter gene of 22 OCD patients compared with control individuals.

Griez, C. Faravelli, D. Nutt and D. Zohar. C. Cavallini and L. Bellodi Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy INTRODUCTION Anxiety disorders are a heterogeneous group of psychiatric disorders with no clear knowledge of their aetiology and pathogenesis. Several familial, biological, and genetic risk factors have been invoked for the obsessive-compulsive disorder (OCD) or the panic disorder (PD), but to date none has shown a main role in their aetiology. The observation that some pharmacological treatments substantially modify the prognosis of affected patients may be one of the main proofs of the role of biological factors in the development of these illnesses.

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