Anti-inflammatory Agents. Chemistry and Pharmacology by Robert A. Scherrer, Michael Whitehouse

By Robert A. Scherrer, Michael Whitehouse

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Ann. Phys. , Suppl. pp. 7-49. Winter, C. A. (1965). Int. Symp. Non-Steroidal Anti-Inflammatory Drugs, Proc, 1964 pp. 190206. Winter, C. , and Flataker, L. (1965). J. Pharmacol. Exp. Ther. 150, 165. , and Fry, J. (1972). Arthritis Rheum. 15, 464. Chapter 3 Aryl- and Heteroarylcarboxylic Acids ROBERT A. SCHERRER Riker Laboratories, Inc. 3M Center St. Paul, Minnesota I. iV-Arylanthranilic Acids A. Introduction B. Structure-Activity Relationships C. Fenamic Acids D. Synthetic Methods II. Heterocyclic Isosteres of N-Arylanthranilic Acids A.

The reverse correlation from anticarrageenan activity is not nearly as good. Because the UV-erythema assay is more specific, it appears likely that its Fig. 4 A possible conformation of PGE2 at the prostaglandin synthetase antiinflamatory receptor (absolute configuration) compared with indomethacin, a potent inhibitor. 38 ROBERT A. SCHERRER Fig. 5 Some antiinflammatory compounds as they are currently envisioned fitting the receptor of Fig. 1. The location of the cationic site is determined by the requirement to satisfy these diverse agents.

It is worthwhile to keep in mind the theoretical therapeutic advantages to be gained by using a combination of agents acting by different mechanisms. It is a mathematical 2. , initiation >inflammation >tissue damage) be synergistic. ) Compounds acting on different pathways to produce the same end may be synergistic or additive in their effects. , 1964). Willoughby's "cocktail" for the treatment of rheumatoid arthritis (Shen, 1972) would include different pharmacological classes of agents. III. ASSESSMENT OF PHARMACOLOGICAL DATA IN THE EVALUATION OF LITERATURE REPORTS Much of the material covered in the chemistry section (Chapters 3 11) is from the patent literature.

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